Thesis, internship, and post-doc opportunities
262 results found
[Thèse]
Study of formation and repair of DNA damage in aniamls exposed to yperite
Offer N°: 5514
Yperite is a war gas used during World War I but that remains a threat because of possible terrorist uses. This chemical induces severe burns of the skin and lung disorders. It is also involved in the induction of cancers. Formation of DNA damage, and in particular addition products to nucleic bases, lies among the possible molecular mechanisms of the action of yperite.
Yperite is a war gas used during World War I but that remains a threat because of possible terrorist uses. This chemical induces severe burns of the skin and lung disorders. It is also involved in the induction of cancers. Formation of DNA damage, and in particular addition products to nucleic bases, lies among the possible molecular mechanisms of the action of yperite. Although partly removed by repair systems, these damage may induce cell death or, in case of replication of cells bearing degraded genome, apparition of mutations. It is thus of importance to delineate the correlation between dose of yperite, amount of DNA adducts, efficiency of DNA repair and appearance of symptoms.
This will represent the subject of the thesis work, in a research project that will involve the laboratory “Lesions of Nucleic Acids” (INAC/SCIB) of the CEA-Grenoble and a group of the Departement of Toxicology of the Institute for Biomedical Research of the Army (IRBA, Grenoble). The first part of the work will consist in the set-up of a method for the measurement of yperite DNA adducts by liquid chromatography associated to mass spectrometry. This tool will then be applied to studies on small animals exposed to yperite through the skin. Dose/effects relationship will be studied between the level of DNA damage and the severity of the symptoms. These results will be completed by investigation of the DNA repair. In addition, measurements will be performed within the DNA of internal organs because yperite efficiently diffuses through blood circulation.
The experimental work is strongly interdisciplinary and candidates with different backgrounds may apply. Because biological studies are focused on small animals, biologists or biochemists with a first experience in animal experimentation will be welcome. They will be trained to the analytical part of the project by the CEA team. Conversely, analytical chemists may also apply bearing in mind that they will have to be trained for the animal work, this being done mostly by the IRBA group.
[Thèse]
Diffusion and rheology of ionic liquid based electrolyte for lithium batteries
Offer N°: 5490
The lithium batteries are currently developped at CEA for theapplication to electric vehicles with an important car constructor. Lithium batteries are mainly constituted of two electrodes positive and negative and an electrolyte. The currently used electrolyte is a lithium salt dissolved in a carbonate solvent and a co-solvant (ether type) for minimizing the viscosity and insuring a large ionic conductivity.
The lithium batteries are currently developped at CEA for theapplication to electric vehicles with an important car constructor. Lithium batteries are mainly constituted of two electrodes positive and negative and an electrolyte. The currently used electrolyte is a lithium salt dissolved in a carbonate solvent and a co-solvant (ether type) for minimizing the viscosity and insuring a large ionic conductivity. For electrochemical stability and security reasons, new electrolyte based on ionic liquid are developped. It appears necessary to understand the transport properties and the rheological properties of these new systems over the requireed temperature range. The PhD thesis will be devoted to characterize the rheological properties of new ionic liquid systems with or without co-solvents and the diffusion properties will be determined using nuclear Magnetic Resonance and neutron quasielastic techniques.
[Thèse]
Optical micro spectrometer integrated on silicon
Offer N°: 2629
This goal of this subject is to develop a new family of micro spectrometers based on the SWIFTS (Stationary Waves Integrated Fourier Transform Spectrograph) principle. This principle consists in sampling with photodetectors stationary waves generated by a reflection at the end of an optical waveguide, in order to obtain instantaneously, and statically an optical spectrum by Fourier Transform.
This goal of this subject is to develop a new family of micro spectrometers based on the SWIFTS (Stationary Waves Integrated Fourier Transform Spectrograph) principle. This principle consists in sampling with photodetectors stationary waves generated by a reflection at the end of an optical waveguide, in order to obtain instantaneously, and statically an optical spectrum by Fourier Transform.
Such a device uses a very small volume, but thanks to the recent progress in silicon photonics technology, it is possible to consider its integration on silicon, for better performances at a reduced price and an in ultimate small volume, enabling new applications such as portable gaz analyzer, spectrometric endoscope for diagnostic, spatial applications, spectroscopic imagery, etc…
The goal of this thesis is therefore to design, realize on silicon, and characterize a micro spectrometer integrated on silicon based on SWIFTS.
[Thèse]
In line characterization and study of spatial deformity generated by stress during MEMS fabrication yielding to their damage
Offer N°: 2627
Performances and fabrication improvements of MEMS yield to an increase of their miniaturization. While their dimension shrink the stress and deformation to which they are submitted become more and more important. So there is a real need to characterize and monitor Microsystems deformations and link them to their performances and integrity at fabrication time.
Performances and fabrication improvements of MEMS yield to an increase of their miniaturization. While their dimension shrink the stress and deformation to which they are submitted become more and more important. So there is a real need to characterize and monitor Microsystems deformations and link them to their performances and integrity at fabrication time. The aim of the thesis is to implement a characterisation toolbox (technique + model) which could be use in-line to monitor the dimension changes and mechanical properties of Microsystems and their constitutive materials. A complementary part will include numerical experiments to understand furthermore the effects of fabrication conditions on MEMS mechanical properties.
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