Development of electrochemical sensors for bloodstream infection diagnosis
Published : 27 February 2019
Blood culture is currently used as a screening method for bloodstream infections. This is a frequent test in clinical microbiology: about one-third of microbiology laboratories activity. This test consists of incubating the blood to be analyzed, after dilution in a nutrient medium. A continuous monitoring is provided during incubation in an automated system to determine whether or not microbial growth occurs in the vial.
In the case of bloodstream infections, exams are urgent and the time to report results has an undeniable impact on the future of patients. The thesis aims to optimize the parameters for electrochemical measurement of CO2 and other metabolites, over a long period and in complex environments. In particular, this will involve the bacteria detection in blood. The kinetics of the pH variation and other metabolites will be studied for the most common pathogens in order to collect a characteristic signature allowing the pathogen identification in addition to its detection.