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Offers : 34

Point-of-Care medical device development for high sensitivity multiplexed detection of blood biomarkers for health care management of cardiac patients

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Start date : 1 September 2020

offer n° SL-DRT-20-0451

Health systems must adapt to new societal and economic constraints that constitute an important challenge to address for the health of tomorrow. In this context, the development of Point-of-Care (POC) devices to carry out in vitro analyses provide valuable assistance to the decision-making of the practitioner for the diagnosis and/or prognosis of the disease. In this context, we propose a PhD subject to explore a new strategy to quantify blood biomarkers (proteins, peptides). This strategy is an alternative to the ELISA gold standard method, based on immuno-detection coupled to enzymatic amplification. We propose an innovative approach to develop a medical device for the high sensitivity detection of various significant blood biomarkers for cardiac diseases. The employed strategy is based on the use of original reagents (aptamers) allowing an isothermal multiplex biomolecular amplification, fast and highly sensitive, coupled with protocol integration and automation inside dedicated microfluidic cartridges. The developed biomedical device will be tested on clinical samples.

Optomechanical reference oscillators

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Start date : 1 September 2020

offer n° SL-DRT-20-0592

Clocks (reference oscillators) are ubiquitous elements in electronic circuits. The arrival of new technologies such as 5G or autonomous vehicles requires a level of performance that is not attainable by commercial clock technologies. One of the most promising routes to improve performance is the development of clocks based on micro-electromechanical (MEMS) resonators at high frequency (1-5 GHz, tens of GHz in the future).

However, it is challenging to build high-performance MEMS resonators in the GHz range, mainly due to the difficulty of detecting their minuscule vibration amplitudes. Recently several groups have demonstrated the possibility of building optomechanical devices in piezoelectric materials. This technology, which was confined to fundamental studies, is now mature enough to evolve towards applications, and solves many of the difficulties involved in the implementation of MEMS clocks in the GHz range.

The objective of the thesis is to develop a MEMS clock based on this novel optomechanical technology. The thesis will take place in the Microsensors Laboratory of the CEA-Leti, in collaboration with the RF Components Laboratory. The Leti is a pioneer in the implementation of on-chip optomechanical and piezoelectric resonators.

The PhD student will work in collaboration with Leti Engineers to design the MEMS resonators and their fabrication process, based on an analytical study and finite-element simulations. Then, the student will have the opportunity to contribute to the fabrication of the devices in clean room. Finally, the student will characterize them in the Leti’s laboratories, to extract their performance and implement a first demonstrator of MEMS clock.

  • Keywords : Engineering science, Materials and applications, DCOS, Leti
  • Laboratory : DCOS / Leti
  • CEA code : SL-DRT-20-0592
  • Contact : marc.sansaperna@cea.fr

Antimicrobial functionalization of nanostructures by initiated Chemical Vapor Deposition

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Start date : 1 October 2020

offer n° SL-DRT-20-0814

The production of antimicrobial and antibiofouling surfaces without antibiotics or nanoparticles is still a challenge despite the needs of a growing number of applications, particularly in the hospital field and more specifically for implanted medical devices. The number of patients infected each year with nosocomial diseases is still too high and infections related to implanted medical devices remain an unresolved problem. The limit of current solutions is their very short lifetime and their rapid fouling by biofilm generation. The scientific community increasingly studied bio-inspired coatings made of polymers with antimicrobial, antibiofouling or switchable functions. However, these coatings are still difficult to achieve by green chemistry on structured surfaces using conventional methods. Initiated Chemical Vapor Deposition (iCVD) is a unique technique for producing polymeric surface coatings on micro structured surfaces while retaining the chemical functions of polymers. The aim of this thesis is to study the feasibility of iCVD deposition of bioinspired polymers with a double switchable function antimicrobial and antibiofouling on nanostructures. The candidate will have a profile of material chemist or polymer chemist with a strong affinity for microbiology and health applications with a MSc in material chemistry or polymer chemistry.

Lensless imaging and artificial intelligence for rapid diagnosis of infections

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Start date : 1 October 2020

offer n° SL-DRT-20-0518

The objective of the thesis is to develop a portable technology for pathogen identification. Indeed, in a context of spread of medical deserts and resurgence of antibiotic-resistant infections, it is urgent to develop innovative techniques for rapid diagnosis of infections in isolated regions. Among optical techniques for pathogen identification, lens free imaging methods draws attention because they are the only ones currently able to offer simultaneous characterization of a large number of colonies, all with low-cost, portable and energy-efficient technology. The objective of the thesis is to explore the potential of lensless imaging combined with artificial intelligence algorithms to identify bacterial colonies present in a biological fluid. The thesis will aim to optimize the sizing of the imaging system (sources, sensors) and to study image processing and machine learning algorithms necessary for colony identification. Two cases of clinical applications will be studied.

  • Keywords : Life Sciences, Biotechnologies,nanobiology, DTBS, Leti
  • Laboratory : DTBS / Leti
  • CEA code : SL-DRT-20-0518
  • Contact : caroline.paulus@cea.fr

Study of Vertical GaN Device Architectures

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Start date : 1 October 2020

offer n° SL-DRT-20-0481

LETI is currently transferring an AlGaN/GaN epitaxy-based power device technology on 200mm Silicon wafers to a well-established industrial partner in the field of power devices (Silicon, SiC,…)

Current GaN transistor technologies that are available on the market have a lateral architecture. They allow to render electric power conversion circuits up to the several 10 kilowatt range. The implementation of a vertical architecture will allow to address power ranges above the megawatt.

The work proposed in this PhD will involve a study aiming to evaluate the performance and physical properties at the basis of the operation of vertical devices using GaN substrates. The tasks will involve as well the management of the device fabrication (epitaxy, deposition, lithography, implantation) and electrical measurements. Finite element simulations (TCAD using Synopsys tools) will be performed in order to tune the dimensions of structures that will be included in a mask set and subsequently be used to test physical hypotheses to interpret the electrical results.

  • Keywords : Engineering science, Electronics and microelectronics - Optoelectronics, DCOS, Leti
  • Laboratory : DCOS / Leti
  • CEA code : SL-DRT-20-0481
  • Contact : julien.buckley@cea.fr
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