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Offers : 10

Biomimetic platforms for molecular and cellular studies

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offer n° 5

Summary: Embryo differentiation but also cancer and tissue homeostasis are supported by the
extracellular matrix (ECM) which has not only a structural but also a functional role: the presentation of
bioactive molecules. The first aim of this project is to mimic the natural presentation of a potent
osteoinductive growth factor, bone morphogenetic protein 2 (BMP-2), by immobilizing it on biomimetic
platforms, together with other ECM adhesion proteins and glycosaminoglycans, in particular heparan
sulfate (HS), as it is in vivo. The second aim is to study cellular responses to BMP-2 presented via the
biomimetic platforms.
Detailed subject: 15 years after FDA approved the clinical use of BMP-2 for spinal cord injuries, raises an
unmet industrial need of optimizing biomaterials for BMP-2 presentation and dose-control. For that is
important to totally understand which are the “molecular regulators” of BMP-2 activity in vivo. Fundamental
studies are therefore needed. We adopt a biomimetic approach to study at the molecular level BMP-2
binding to the natural ligand HS and the cellular responses to this type of presentation.
We design surfaces — biomimetic platforms — that present some selected components of the ECM bound
to them. On the biomimetic platforms we will graft HS, BMP-2 and also adhesion ligands (here called RGD
peptides), which permit cells spreading via cellular adhesion receptors: integrins (Fig 1).
We have shown that the presentation of BMP-2 via HS promotes the osteogenic differentiation of
progenitor cells (Migliorini et al. 2017). To understand the molecular mechanism behind the role of HS on
BMP-2 bioactivity we immobilize biotinylated HS with different chemical composition on SAv monolayer.
With quartz crystal microbalance with dissipation monitoring (QCM-D) we will characterize the binding of
biotiylated molecules on the top of SAv and calculate the average nanometrical distances between ligands.
After the characterization of the molecular assembling, we will use the well-defined biomimetic platforms for
studying cellular adhesion and differentiation with molecular biology methods.
Related Publication: Migliorini, E., P. Horn, T. Haraszti, SV Wegner, C. Hiepen, P. Knaus, PR. Richter,
and EA. Cavalcanti-Adam. 2017. ‘Enhanced biological activity of BMP-2 bound to surface-grafted heparan
sulfate’, Advanced Biosystems, 1: 1600041.
Background and skills: master student from last year university or engineering school interested in
glycobiology and/or physical chemistry. Aptitude for teamwork, good spoken and written English are
required. A “gratification” will be provided following the French law.
Supervisor : Migliorini Elisa
Laboratory : LMGP – CNRS-UMR 5628
Team/Group : IMBM
Contacts – E-mail : elisa.migliorini@grenoble-inp.fr Tel : +33 4 56529324 Web-page :
http://www.lmgp.grenoble-inp.fr/annuaire-/migliorini-elisa–869551.kjsp?RH=LMGP_ANNUAIRE
This project is part of the core interest of the main investigator, therefore a PhD thesis might follow the
master thesis. Please send a CV + a cover letter (including names/contact email of 2 referees) + the record
of your grades of the 2 past academic years to: elisa.migliorini@grenoble-inp.fr2018-19 Master proposalE.MIGLIORINIpdf

Deposition of oxide thin films via Spatial Atomic Layer Deposition: in search of high quality oxide semiconductors for electronic and optoelectronic applications

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offer n° 4

Project description
In ever more challenging environmental conditions an increasing amount of scientific work is devoted to the investigation of new materials for energy applications. But apart from finding better materials, new processing tools need to be developed allowing the scalable deposition of high quality materials at low temperatures. Atomic Layer Deposition (ALD) is an attractive candidate since it has unique unrivalled features including: i) a highly precise control of layer thickness; ii) the capability of depositing uniform and conformal coatings even on high aspect ratio features; and iii) the possibility to deposit high quality films at low temperatures. These qualities are a result of ALD mechanism: ALD is a particular case of Chemical Vapor Deposition (CVD) in which the reaction is restricted to the sample surface, thus being self-limited. This is achieved by exposing the sample to the reactants at different time, i.e. in a sequence of pulses. In this way, the metal precursors are supplied and react with the surface, ideally forming a monolayer. Excess precursor is then purged, usually by evacuation. The second precursor is then injected and reacts with the chemisorbed layer forming a monolayer of the desired material plus by-products that have to be purged along with the excess precursor. The cycle is then repeated the necessary number of times to obtain a very precise film thickness. But also as a result of the ALD particular mechanism, deposition rates are very low and vacuum processing makes it complicated and expensive to scale up.
Recently, a new approach to atomic layer deposition (ALD) has been developed that doesn’t require vacuum and is much faster than conventional ALD. This is achieved by separating the precursors in space rather than in time. This approach is most commonly called Spatial ALD (SALD). In the LMGP we have developing a novel atmospheric SALD system to fabricate active components for new generation solar cells and other applications, showing the potential of this novel technique for the fabrication of high quality materials that can be integrated into devices.
References: David Muñoz-Rojas*, and Judith L. MacManus-Driscoll. Materials Horizons, 1, 314-320, 2014.
Work requested (Subject internship)
The goal of this internship is to work within a team aiming at optimising the deposition of high quality oxide films, (Cu2O, ZnO, TiO2,…), by SALD. The final objective is to be able to tune the properties of the films both by adjusting the deposition parameters and via doping in order to use the materials in solar cells and TFTs, among others.
The physical properties (chemical composition, crystallographic structure, electrical conductivity, optical transparency, mechanical properties) of the films will be thoroughly investigated and optimized as well by using appropriate thermal annealing. The LMGP houses state of the art experimental equipments for investigating such properties. X-Ray diffraction (XRD), spectrophotometry, optical and electron microscopy will be routinely used to get a better understanding of the relationships between microstructure and physical properties for as-deposited and thermally treated films.
Location
Located in the heart of an exceptional scientific environment, the « Laboratoire des Matériaux et du Génie Physique » (LMGP) offers the applicant a rewarding place to work. The applicant will be integrated within a team and in close collaboration with surrounding laboratories (CEA-Grenoble, Institut Néel, SIMAP…).
LMGP Web Site: http://www.lmgp.grenoble-inp.EN/
Profile & requested skills
The candidate must have a good ranking (top 25%) in master or engineering school. Ideally, (s)he should have some experience in surface chemistry and materials sciences. We are looking for a highly motivated student who is interested to work in an inter-disciplinary group and on an interdisciplinary project. Interpersonal skills, dynamism, rigor and teamwork abilities will be appreciated. Candidates can be fluent either in English or in French.
Subject could be continued with a PhD thesis : YES
Allowance : Internship allowance will be provided.
CONTACT
David MUÑOZ-ROJAS: david.munoz-rojas@grenoble-inp.fr

Optimization of a Spatial Atomic Layer Deposition system by simulation

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offer n° 3

Project description
In ever more challenging environmental conditions an increasing amount of scientific work is devoted to the investigation of new materials for energy applications. But apart from finding better materials, new processing tools need to be developed allowing the scalable deposition of high quality materials at low temperatures. Atomic Layer Deposition (ALD) is an attractive candidate since it has unique unrivalled features including: i) a highly precise control of layer thickness; ii) the capability of depositing uniform and conformal coatings even on high aspect ratio features; and iii) the possibility to deposit high quality films at low temperatures. These qualities are a result of ALD mechanism: ALD is a particular case of Chemical Vapor Deposition (CVD) in which the reaction is restricted to the sample surface, thus being self-limited. This is achieved by exposing the sample to the reactants at different time, i.e. in a sequence of pulses. In this way, the metal precursors are supplied and react with the surface, ideally forming a monolayer. Excess precursor is then purged, usually by evacuation. The second precursor is then injected and reacts with the chemisorbed layer forming a monolayer of the desired material plus by-products that have to be purged along with the excess precursor. The cycle is then repeated the necessary number of times to obtain a very precise film thickness. But also as a result of the ALD particular mechanism, deposition rates are very low and vacuum processing makes it complicated and expensive to scale up.
Recently, a new approach to atomic layer deposition (ALD) has been developed that doesn’t require vacuum and is much faster than conventional ALD. This is achieved by separating the precursors in space rather than in time. This approach is most commonly called Spatial ALD (SALD). In the LMGP we have developing a novel atmospheric SALD system to fabricate active components for new generation solar cells and other applications, showing the potential of this novel technique for the fabrication of high quality materials that can be integrated into devices. Our system is based on an injection manifold head in which the different gas flows are distributed along parallel channels.
References: David Muñoz-Rojas*, and Judith L. MacManus-Driscoll. Materials Horizons, 1, 314-320, 2014.
Work requested (Subject internship)
The goal of this internship is to work within a team aiming at optimising the SALD system by using modelling approaches to optimize the injector head design. COMSOL will be used to evaluate the optimum head designs and the optimum deposition conditions for different head designs. The results obtained from the modelling will be use to fabricate improved head which will be tested in the system.
The LMGP has a long experience in modelling and houses state of the art experimental equipments for materials characterization.
Location
Located in the heart of an exceptional scientific environment, the « Laboratoire des Matériaux et du Génie Physique » (LMGP) offers the applicant a rewarding place to work. The applicant will be integrated within a team and in close collaboration with surrounding laboratories (CEA-Grenoble, Institut Néel, SIMAP…).
LMGP Web Site: http://www.lmgp.grenoble-inp.EN/
Profile & requested skills
The candidate must have a good ranking (top 25%) in master or engineering school. Ideally, (s)he should have some experience in surface chemistry and materials sciences. We are looking for a highly motivated student who is interested to work in an inter-disciplinary group and on an interdisciplinary project. Interpersonal skills
Subject could be continued with a PhD thesis : YES
Allowance : Internship allowance will be provided.
CONTACT
David MUÑOZ-ROJAS: david.munoz-rojas@grenoble-inp.fr

(filled) Modeling and simulation of superconducting phi-junctions and bi-SQUIDs

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offer n° IMEPLaHC-01232018-CMNE

                                                                          MASTER INTERNSHIP 2018                                                 

                                                     Modeling & simulation of superconducting phi-junctions and bi-SQUIDs

The Laboratory of Microwave and Characterization (IMEP-LAHC, CNRS UMR 5130) of Université Savoie Mont Blanc located in the French Alps area develops ultrafast energy-efficient superconducting digital circuits that work with clock frequencies of several tens of GHz, based on the Rapid Single-Flux Quantum (RSFQ) technology. Such circuits use a binary dynamic logic derived from the underlying physics of shunted Josephson junctions in free-running mode. In present of forced oscillations the strong non-linearity of Josephson junctions leads to the generation of harmonics or frequency mixing depending on the input signals. These effects are used for instance in radioastronomy and have enabled the development of quantum-sensitive terahertz (THz)
receivers, used at the focal point of ground-, balloon- and space-based telescopes.

The objective of this internship is to go one step further and develop new kinds of devices for usage in several additional domains, like security, medicine or telecommunications systems. That is possible by combining analogue and digital devices to build all-superconducting mixed-signal systems. Such developments can also be interesting for the readout of quantum-accurate imagers, magnetometers or quantum computing systems.

The objective of this internship is to focus on two relatively new types of superconducting devices, namely phijunctions [1] and bi-SQUIDs [2]. The work consists of developing specific SPICE-like models and design-tools, based on MatLab or on Python for instance, to predict the behaviour of such devices and incorporate them in superconducting electronics circuits to perform specific tasks. For both devices experimental measurements have been made in the past so that it is possible to compare with the results of simulations.

An education in physics and computer science is best suited to achieve the objectives of this subject.
[1] Menditto, R., Sickinger, H., Weides, M., Kohlstedt, H., Koelle, D., Kleiner, R., & Goldobin, E., “Tunable φ Josephson
junction ratchet. Physical Review E, 94(4), 042202, 2016.
[2] Victor K. Kornev, Nikolay V. Kolotinskiy, Daniil E. Bazulin and Oleg A. Mukhanov, ” High-Inductance Bi SQUID,”
IEEE Trans. Applied Superconductivity, Vol.. 27, No. 4, 1601304, June 2017

Education: Engineering school or master level students

Contact : Pascal Febvre – phone : +33-4-79-75-88-64
Address : Université Savoie Mont Blanc
IMEP-LaHC – CNRS UMR5130
Campus scientifique
73376 Le Bourget du Lac Cedex- France

Internship duration: 4 to 6 months during the January-July 2018 period
Accommodation : Student’s rooms are available on campus for a monthly rent of about 200 euros.
https://www.crous-grenoble.fr/wp-content/uploads/sites/7/2017/06/GuidesResidenceCLOUS-WEB.pdf
This internship comes with a stipend of 554.40 € per month.

  • Keywords : Engineering science, Electronics and microelectronics - Optoelectronics, FMNT, IMEP-LaHc
  • Laboratory : FMNT / IMEP-LaHc
  • CEA code : IMEPLaHC-01232018-CMNE
  • Contact : Pascal.Febvre@univ-smb.fr
  • This Internship position has been filled. Thank you for your interest

(filled) Development of a simulation software of superconducting electronics based on the use of Josephson junctions at terahertz frequencies

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offer n° IMEPLaHC-01242018-CMNE

                                      MASTER INTERNSHIP 2018                                            

      Development of a simulation software of superconducting electronics based on the use of Josephson junctions at terahertz frequencies

The Laboratory of Microwave and Characterization (IMEP-LAHC, CNRS UMR 5130) of Université Savoie Mont Blanc located in the French Alps area develops ultrafast energy-efficient superconducting digital circuits that work with clock frequencies of several tens of GHz, based on the Rapid Single-Flux Quantum (RSFQ) technology. Such circuits use a binary dynamic logic derived from the underlying physics of shunted Josephson junctions in free-running mode. In present of forced oscillations the strong non-linearity of Josephson junctions leads to the generation of harmonics or frequency mixing depending on the input signals. These effects are used for instance in radioastronomy and has enabled the development of quantum-sensitive terahertz (THz) receivers,
used at the focal point of ground-, balloon- and space-based telescopes.

The objective of this internship is to go one step further and develop new kinds of devices for usage in several additional domains, like security, medicine or telecommunications systems. That is possible by combining analogue and digital devices to build all-superconducting mixed-signal systems. Such developments can also be interesting for the readout of quantum-accurate imagers, magnetometers or quantum computing systems.

To do so we need to develop user-friendly softwares that can enable the simulation of systems based on Josephson junctions. For this particular subject, the work will be focused on the analogue mode of operation of Josephson junctions in the THz domain. The objective of the work is to build a user-friendly software
programmed in C/C++ or Python for instance and that can be compiled to run on different operating systems (at least Linux and MacOSX). The student will benefit at the beginning of a dedicated education to deal with the detailed physics of Josephson junctions. Some preliminary kernel codes, written in Fortran, already exist. The full formalism of equations to be used is also ready.

An education in physics and computer science is best suited to achieve the objectives of this subject.

Education: Engineering school or master level students

Contact : Pascal Febvre – phone : +33-4-79-75-88-64

Address : Université Savoie Mont Blanc
IMEP-LAHC – CNRS UMR5130
Campus scientifique
73376 Le Bourget du Lac Cedex- France

Internship duration: 4 to 6 months during the January-July 2018 period

Accommodation : Student’s rooms are available on campus for a monthly rent of about 200 euros.
https://www.crous-grenoble.fr/wp-content/uploads/sites/7/2017/06/GuidesResidenceCLOUS-WEB.pdf
This internship comes with a stipend of 554.40 € per month.

  • Keywords : Engineering science, Electronics and microelectronics - Optoelectronics, FMNT, IMEP-LaHc
  • Laboratory : FMNT / IMEP-LaHc
  • CEA code : IMEPLaHC-01242018-CMNE
  • Contact : Pascal.Febvre@univ-smb.fr
  • This Internship position has been filled. Thank you for your interest
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